Amakuru

Amateka nubwihindurize bwa Anesthenous

Ubuyobozi bw'ibiyobyabwenge bwatangiye mu kinyejana cya cumi na karindwi iyo Christopher Wren yateye inshinge mu mbwa akoresheje ingagi akoresheje ingagi no mu ruhago ruhinduka 'stupefied'. Mu myaka ya za 1930 Hexobarbital na Pentothal bamenyeshejwe mubikorwa byubuvuzi.

Byari mu myaka ya za 1960 iyo moderi n'uburinganire ku muvuduko wa IV washinzwe kandi mu myaka ya za 1980, Sisitemu igenzurwa na mudasobwa iv. Muri 1996 intego yambere igenzurwa na sisitemu ya infusion ('DipruUsor') yatangijwe.

Ibisobanuro

A intego igenzurwani infusion igenzurwa muburyo bwo kugerageza kugera ku mukoresha wasobanuwe kwibanda ku mibiri mu rwego rwo gutandukanya inyungu cyangwa ibice byinyungu. Iki gitekerezo cyabanje gutangajwe na Kruger Thiemer mu 1968.

Farumasikotics

Ingano yo gukwirakwiza.

Ubu ni bwo buryo bugaragara ibiyobyabwenge bitangwa. Irabarwa na formula: vd = dose / kwibanda kubiyobyabwenge. Agaciro kayo gashingiye kubijyanye no kubarwa mugihe zeru - nyuma ya bolus (VC) cyangwa muburyo buhamye nyuma yizuba (vss).

Kwemererwa.

Ibisobanuro byerekana ingano ya plasma (VP) bivuyemo ibiyobyabwenge byakuweho kuri buri gihe cyo kubara burundu mumubiri. Kwemeza = Kurandura X VP.

Nkuko icyemezo cyongera ubuzima-ubuzima bugabanya, kandi nkuko ubwinshi bwo kugabura bwiyongera kuburyo bukora kimwe cya kabiri. Kwemeza nabyo birashobora gukoreshwa mugusobanura uburyo ibiyobyabwenge byihuta hagati yimpamba. Ibiyobyabwenge bitabanje gukwirakwizwa mu gice cyo hagati mbere yo gukwirakwiza ibice bya peripheri. Niba ingano ya mbere yo gukwirakwiza (VC) hamwe nubushakashatsi bwifuzwa kubwingaruka zubuvuzi (CP) birazwi, birashoboka kubara igipimo cyo gupakira kugirango ubigereho icyo kwibandaho:

Gutwara Dose = CP X VC

Irashobora kandi gukoreshwa mugukamira igipimo cya Bolus gisabwa byihuse kwibanda mugihe cyo gukomeza: Bolus dose = (CNEW - imyenga) x VC. Igipimo cyo kwinjizamo kubungabunga leta zihamye = CP X.

Tegens yoroshye ya infunosi yoroshye ntabwo igera kuri plasma ihamye ya plasma kugeza byibuze bitanu byinshi byo kurandura kabiri. Icyifuzo cyifuzwa kirashobora kugerwaho vuba niba igipimo cya Bolus gikurikirwa nigipimo cyurugero.